Due to its α-symphathomimetic effect, this agent has topical and systemic side effects. Naphazoline Hydrochloride, an ocular vasoconstrictor, is an imidazoline derivative sympathomimetic amine. Symptoms of overdose. 2009 May-Jun. Toxicity. Naphazoline HCl prescription and dosage sizes information for physicians and healthcare professionals. Accidental poisoning with naphazoline («PRIVINE») hydrochlorid. drowsiness. Naphazoline is a medicine used as a decongestant.It is a sympathomimetic agent with marked alpha adrenergic activity. Substances predicted as likely to meet criteria for category 1A or 1B carcinogenicity, mutagenicity, or reproductive toxicity. In three cases of intentional ingestion of an antiseptic liquid containing naphazoline there was acute pulmonary edema, altered mental status, hypertension, bradycardia, and sweating; two required mechanical ventilation and all of the clinical effects resolved within 24 hours [ 18 ]. I found the information and suggest the Puppy see the ER Vet as the main ingredient Naphazoline Hydrochloride is toxic if ingested. These side effects may go away during treatment as your body adjusts to the medicine. Use this medication in the nose as directed. Hydrochloric acid poisoning. In published reports of naphazoline ingestion, clinical effects are hypertension, bradycardia, pallor, diaphoresis, and respiratory distress. It occurs as a white, odorless crystalline powder having a bitter taste and is freely soluble in water and in alcohol. Use should be discontinued if symptoms worsen or persist for more than 72 hours. Acute pulmonary edema associated with naphazoline ingestion. Pharmacology, adverse reactions, warnings and side effects. Product name : Naphazoline hydrochloride CAS-No. How to use Naphazoline Spray, Non-Aerosol. Pre-registered substances Substances indicated, in 2009, as being intended to be registered by at least one company in the EEA. Am J Dis Child. Naphazoline (hydrochloride) SAFETY DATA SHEET Supersedes Revision:12/26/2017 according to Regulation (EC) No. It is a vasoconstrictor with a rapid action in reducing swelling when applied to mucous membrane.It acts on alpha-receptors in the arterioles of the conjunctiva to produce constriction, resulting in decreased congestion. Atropine doubled HR, but caused a marked rise in MAP, too, stressing the adverse effects of atropine in these cases. 47. Do NOT use it … 17852165. Hydrochloric acid is a clear, poisonous liquid. : 550-99-2 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratorychemicals, Industrial & for professional use only. 2008 Mar. Half-life of tetryzoline in healthy people is about 6 hours and it is excreted unchanged in urine, at least in part. Combination of an ocular antihistamine and decongestant. 1907/2006 as amended by (EC) No. Winston C. Hainsworth. In high doses or when ingested, naphazoline can lead to central nervous system … Identification of the Substance/Mixture and of the Company/Undertaking Product Name: Naphazoline (hydrochloride) slow heartbeat. In case of accidental ingestion, seek professional assistance or contact a Poison Control Center immediately. Structure. Pharmacokinetics. The reports on this medication suggest a charcoal lavage to bind the toxins, and supportive care which will include an anti nausea medication and fluids. 1948;75(1):76-80. weakness (severe) Some side effects may occur that usually do not need medical attention. Drug Name Active Ingredients Strength Dosage Form/Route Marketing Status TE Code RLD RS; NAPHCON-A: NAPHAZOLINE HYDROCHLORIDE; PHENIRAMINE MALEATE: 0.025%;0.3% Even a small ingestion can cause clinical signs of vomiting, lethargy/depression or agitation, ataxia (incoordination), hypotension, and a life-threatening low heart rate. Naphcon … Naphazoline is a vasoconstrictor. Fortunately, its toxic reactions have been confined to mild local and rare systemic effects.The following case … It is a caustic chemical and highly corrosive, which means it immediately causes severe damage to tissues, such as burning, on contact. 2015/830 and US OSHA HCS 2015 1.1 Product Code: 23774 Section 1. Decrease in body temperature. naphazoline doubled mean arterial pressure (MAP) and reduced heart rate (HR) from 167 to 30 beats/min. Naphazoline is an imidazole derivative and a direct-acting sympathomimetic amine with vasoconstrictive activity. Naphcon A (naphazoline hydrochloride and pheniramine maleate) is a combination of a decongestant /redness reliever and an antihistamine used for the temporary relief of redness and itching of the eye (s) due to ragweed pollen, grass, and animal dander and hair. Used for the temporary relief of redness and itching of the eye due to pollen, ragweed, grass, animal hair and dander. The imidazoline derivatives, oxymetazoline, xylometazoline, tetrahydrozoline, and naphazoline, are found in topical ophthalmic and nasal decongestants available OTC. Use of Naphazoline hydrochloride Naphazoline HCl is an ocular vasoconstrictor and imidazoline derivative sympathomimetic amine.Target: Adrenergic Receptorphazoline hydrochloride is the common name for 2-(1-naphthylmethyl)-2-imidazoline hydrochloride. : 550-99-2 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, manufacture of substances. 48. There is no antidote for tetryzoline or other similar imidazoline analogue poisoning, but the symptoms can be alleviated and with treatment, death is rare. 1.3 Details of the supplier of the safety data sheet Company: MedChemExpress USA Tel: 609-228-6898 Fax: 609-228-5909 Serving Faculty and Staff in Norman, Oklahoma City, and Tulsa campuses. This article is for information only. It works by narrowing swollen blood vessels in the eyes to reduce eye redness. Yamadori Y, Oiso N, Hirao A, Kawara S, Kawada A. Allergic contact dermatitis from dibucaine hydrochloride, chlorpheniramine maleate, and naphazoline hydrochloride in an over-the-counter topical antiseptic. Naphazoline belongs to the imidazoline class of sympathomimetics. I.v. 550-99-2 - DJDFFEBSKJCGHC-UHFFFAOYSA-N - Naphazoline hydrochloride [USP:JAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information. naphazoline are frequently used as local vasoconstrictive and decongestant drugs. This medication is used to temporarily relieve eye redness, puffiness, itching, and watering that commonly occur with allergies. Upon ocular administration, naphazoline exerts its effect by acting on alpha-adrenergic receptors in the arterioles of the conjunctiva to produce vasoconstriction, resulting in decreased conjunctival congestion and diminished itching, irritation and redness. ... Flow-injection chemiluminescence method for the determination of naphazoline hydrochloride and oxymetazoline hydrochloride. Inappropriate use or unintentional ingestion of naphazoline can quickly cause A conscious rabbit was injected with naphazoline and thereafter with atropine. It is a sympathomimetic agent with marked alpha adrenergic activity. Human Resources for the University of Oklahoma. Naphazoline is a decongestant. Follow all directions on the product package, or use as directed by your doctor. Reactive hyperaemia and atrophic rhinitis sicca are well-known local side effects. Naphazoline hydrochloride Revision Date 19-Jan-2018 Precautionary Statements Prevention Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product Ingestion IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician Rinse mouth Storage Store locked up Disposal Product name : Naphazoline (hydrochloride) Catalog No. NAPHAZOLINE hydrochloride N. N. R. ("privine hydrochloride") was introduced in 1942; since that time it has become one of the widely used nasal vasoconstrictors. 19253271 [Microhemocirculation and its correction in duodenal ulcer during period of rehabilitation]. : HY-B0446 CAS No. Accidental oral ingestion in infants and children may lead to coma and marked reduction in body temperature. Immediate veterinary attention should be sought following ingestion. Blood vessels in the naphazoline hydrochloride ingestion to reduce eye redness, puffiness, itching, and,! 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